Malleability of the SARS-CoV-2 3CL Mpro Active-Site Cavity Facilitates Binding of Clinical Antivirals
نویسندگان
چکیده
منابع مشابه
SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity.
The 3C-like protease (3CLpro) of severe acute respiratory syndrome coronavirus (SARS-CoV) cleaves 11 sites in the polyproteins, including its own N- and C-terminal autoprocessing sites, by recognizing P4-P1 and P1'. In this study, we determined the crystal structure of 3CLpro with the C-terminal prosequence and the catalytic-site C145A mutation, in which the enzyme binds the C-terminal proseque...
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ژورنال
عنوان ژورنال: Structure
سال: 2020
ISSN: 0969-2126
DOI: 10.1016/j.str.2020.10.007